Insulin potentiation therapy (IPT), also known as Insulin Potentiation Targeted Low-Dose (IPTLD), is a cancer treatment that utilizes insulin alongside smaller amounts of chemotherapy. IPT is known as a gentler and less intrusive approach to cancer treatment with very few of the undesirable effects that are typically associated with traditional chemotherapy. IPT uses a small fraction of the standard dose of chemotherapy treatment to achieve the same results. The impact of chemotherapy is increased by the insulin.


How Does IPT Work?


Insulin potentiation therapy utilizes the hormone insulin, which the body makes naturally.


Doctors who advocate IPT suggest that insulin increases the permeability of cancer cell membranes so that an increased amount of chemotherapy medicine can be absorbed. A Georgetown University Medical School study in the 1990s showed the chemotherapy drug methotrexate had the ability to enter cancer cells at a rate 10,000 times greater when the cells were prepared with insulin.


This allows doctors to use a reduced dose of chemotherapy with the same cytotoxic effects. Lower-dose chemotherapy means less toxicity to normal cells and fewer side effects for patients. The goal is to make pharmacological treatments more effective.


Insulin potentiation therapy has also been utilized to ease symptoms of arthritis, chronic fatigue, fibromyalgia and certain infections.


Typical IPT Cancer Treatment


Typical IPT treatment is much less unpleasant than traditional chemotherapy. Here is what you can expect:


Patients are asked to refrain from eating and drinking (aside from water) for six to eight hours prior to treatment. Patients are given a dosage of insulin intravenously. When the insulin reaches the bloodstream and glucose levels begin to decline, small amounts of chemotherapy are administered.


At this time, the patient typically has signs of low glucose levels (hypoglycemia). These may be quite serious, particularly during first treatment. Blood sugar is then raised by IV. After the signs of hypoglycemia begin to show improvement, the patient is also provided with food to lift the glucose levels yet again. Throughout the treatment, glucose levels continue to be monitored.


At the following treatment, the dose of insulin is also adjusted, according to the patient’s reaction to the primary dose. Patients may take chemotherapy medication orally and are sometimes given supplements and vitamins. Patients are treated twelve to eighteen times, sometimes twice per week. Once the first series of treatment is complete, some patients may require further maintenance sessions.


History of IPT


Doctors first realized the medicinal properties of insulin in the 1920s. Since then, it is most commonly used for treatment of diabetes. In the 1930s, insulin was used to induce comas in schizophrenic patients in an effort to ease their psychological symptoms. Insulin is no longer used to treat schizophrenia.


Dr. Donato Perez Garcia, Sr. first pioneered the use of IPT in Mexico, when physicians were beginning to use insulin treatment in schizophrenics. At this time, cancer patients were also placed into insulin-induced comas. Dr. Perez Garcia went on to use what is now known as IPT to treat many forms of cancer.


Is IPT an Option for Me?


Choosing the right cancer treatment can be an overwhelming and confusing process. If you aren’t convinced that traditional treatment is right for you, or you are looking to supplement traditional treatment with alternatives, then IPT might be a viable option.


While low-dose chemotherapy uses the same chemotherapeutic agents as conventional chemotherapy treatments, this low-dose method in combination with insulin potentiation therapy is not widely recognized among conventional oncologists. Proponents of IPT are adamant about a gentler approach to chemotherapy that has shown signs of being effective.


As with any medical treatment, be sure to consult your doctor, do your research, or contact Angeles Health for a consultation.